2010 Conference Calendar

THE TWENTY-FIFTH ASPEN CANCER CONFERENCE:
MECHANISMS OF TOXICITY, CARCINOGENESIS,
CANCER PREVENTION AND CANCER THERAPY 2010

Click here for a printable PDF of our agenda

Saturday, July 10, 2010

5:30 - 6:30 Registration (Optional)

Sunday, July 11, 2010

7:30 - 8:00 Registration and Breakfast

8:00 - 8:10 Welcome Curtis Harris

SESSION 1: PI3 KINASE

8:10 - 8:20 Introduction by Chairperson Scott Lowe

8:20 - 8:40 PI 3-Kinase and Cancer Cell Metabolism Lew Cantley

8:40 - 9:00 Discussion

9:00 - 9:20 PI3K Inhibitors for the Treatment of Solid Tumors: From
Translational Research to the Clinic Michel Maira

9:20 - 9:40 Discussion

9:40 - 10:10 Break

SESSION 2: CANCER STEM CELL REVIEW

10:10 -10:20      Introduction by Chairperson                          Stuart Yuspa

10:20 -10:40     Some Cancers Follow a Stem Cell Model, While Other Cancers
                          have Common Tumorigenic Cells with Little Hierarchical
                          Organization                                                    Sean Morrison
10:40 -11:00    Discussion

11:00 -11:20 Microenvironment Modulation of Asymmetric Cell Division
in Human Lung Cancer Sharon Pine

11:20 -11:40 Discussion

SESSION 3: EARLY TUMOR HETEROGENEITY AND MICRO ENVIRONMENT

11:40 -11:50     Introduction by Chairperson                               Robert Radinsky

11:50 -12:10     Mechanisms Regulating Mammary Tumor Progression,                           Metastasis and Response to Therapy                Zena Werb

12:10 -12:30     Discussion

SESSION 4: UPDATE FROM THE FDA

12:30 – 12:40 Introduction by Chairperson Lee Silverman

12:40 – 1:00 Genomics in Regulatory Submissions:
Update from the FDA John Leighton

1:00 - 1:20 Discussion

LUNCH

5:30 – 7:00 RECEPTION AND POSTER ABSTRACTS PRESENTATION OF THE THEODORE T. PUCK AWARD AND THE BENJAMIN F. TRUMP AWARD

7:00 – 8:00 KEYNOTE ADDRESS – MICHAEL BISHOP
INTRODUCTION BY CURTIS C. HARRIS

Monday, July 12, 2010

7:30 - 8:00 Breakfast

SESSION 5: DEVELOPMENTAL BIOLOGY AND CANCER

8:00 - 8:10       Introduction by Chairperson                                Cheryl Walker

8:10 - 8:30       Targeting the Hedgehog Pathway in Cancer     Fred de Sauvage

8:30 - 8:50 Discussion

8:50 - 9:10 Hippo Signaling in Development and Cancer D. J. Pan

9:10 - 9:30 Discussion

SESSION 6: IMPROVED CLINICAL TRIALS

9:30 – 9:40 Introduction by Chairperson Richard Gaynor

9:40 10:00 Adaptive Biomarker-driven Clinical Trials Don Berry

10:00 –10:20 Discussion

10:20 -10:50 Break (Group Photo)

SESSION 7: RNAi: IDENTIFICATION OF CANCER GENES AND THERAPEUTICS

10:50-11:00      Introduction by Chairperson                                           Bill Kaelin

11:00-11:20      Systematic Functional Approaches to Identify
                         Cancer Targets and Dependencies                  William Hahn

11:20–11:40      Discussion

11:40-12:00      RNAi Screening and Cancer Gene Resequencing for the Achilles
                         Heel of Cancer                                                               Lou Staudt

12:00-12:20 Discussion

SESSION 8: AUTOPHAGY

12:20-12:30       Introduction by Chairperson                       Webster Cavenee

12:30-12:50       To Be Provided                                              Eileen White

12:50 - 1:10       Discussion

LUNCH

5:30 – 6:30 RECEPTION - MUSIC

6:30 – 7:30          SPECIAL SESSION
                             SCIENCE AND THE MEDIA – MARILYN CHASE
                             INTRODUCTION BY MICHAEL BISHOP

Tuesday, July 13, 2010

7:30 - 8:00 Breakfast

SESSION 9: HEALTH DISPARITIES

8:00 - 8:10 Introduction by Chairperson Curtis Harris

8:10 - 8:30 To Be Provided Otis Brawley

8:30 - 8:50 Discussion

8:50 - 9:10 Profiling of Tumors to Identify Factors that Contribute to
Cancer Health Disparities Stefan Ambs

9:10 - 9:30 Discussion

SESSION 10: BREAST CANCER AND PROSTATE CANCER

9:30 – 9:40       Introduction by Chairperson                                 Thea Tlsty

9:40 -10:00       Regulation of Transcription Elongation During
                          Mammary Gland Development and
                          Tumorigenesis                                                     Rong Li

10:00 -10:20       Discussion

10:20 -10:50 Break

10:50 -11:10      Breast Cancer Metastasis and Dormancy:
                             Experimental Studies and Clinical Implications                                                                                                                         Ann Chambers

11:10 -11:30       Discussion

11:30 -11:50 Breast Cancer Therapy Rachel Schiff

11:50 -12:10 Prostate Cancer Therapy David Bostwick

12:10 -12:30 Discussion of Therapy I and II

SESSION 11: THE BENJAMIN F. TRUMP LECTURE

12:30 –12:40       Introduction by Chairperson                                Ray DuBois

12:40 – 1:00        Inflammation, Senescence and Cancer:
                             Interweaving MicroRNA, Inflammatory
                             Cytokines and p53 Networks                             Curtis Harris

1:00 – 1:20 Discussion

LUNCH

1:30 – 3:00 Advisory Committee

END OF THE TWENTY-FIFTH ASPEN CANCER CONFERENCE

CONFERENCE EXCELLENCE FROM THE
LABORATORY TO THE CLINIC